Plasma Catechol Amine Concentrations
نویسندگان
چکیده
T HERE have been many reports that the adrenergic eateehol amines (epinephrine and norepinephrine) cause a wastage of oxygen by the heart muscle that exceeds the simultaneous oxidative energy requirements for mechanical work. Recently, however, Katz' suggested a "stress-adapting mechaiiisms" related to the catechol amines that appears to make the heart more efficient in the utilization of oxygen in the experimental animal. In either event with cases of myocardial infarction or angina pectoris an excess of these amines may be of cliinical significance. Raab,' 3 utilizing a modification of Shaw's colorimetric method, showed an increase in blood catechol amines in 7 patients with angina after exercise as compared to 14 normal cases. However, this method has subsequently been shown to be insufficiently sensitive to measure minute quantities in blood.4 Nuzum and Bisehoff5 found increased amounts of epinephrine in the urine of 2 patients with myoeardial infarction and 1 of these showed such amounts on 4 occasions. Raab and Gigee,6 on the other hand, were unable to detect grossly abnormal total urinary catechol excretion in patients with myocardial infarction, arterial hypertension, congestive failure or in states of emotional tension. They7 performed colorimetric determinations of total eatechol amine content and bioassay of norepinephrine and epinephrine separately in 85
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متن کاملThe Catechol Amine Content of Various Organs of the Cat After Injections and Infusions of Adrenaline and Noradrenaline
Infusions of 2.5-7.8 ng. noradrenaline/Kg./min. over 30 min. and intruperitonenl injections of noradrenaline and adrenaline up to 2000 Mg/Kg. in the cat had no effect on the catechol amine content of the. heart, spleen, liver, kidney and skeletal muscle, except for a slight increase in the adrenaline content. It is concluded that these organs lack the ability to accumulate i-iirulating catechol...
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